Pepsin A
pepsin
CAS: 9001-75-6
Molecular Formula:
Pepsin A - Names and Identifiers
| Name | pepsin |
| Synonyms | pepsin Pepsin A AVIANPEPSIN BOVINEPEPSINB BOVINEPEPSINA IMMOBILIZED PEPSIN Pepsin(porcine stoMach Mucose) OMniTrace Ultra (TM) Perchloric Acid |
| CAS | 9001-75-6 |
| EINECS | 232-629-3 |
Pepsin A - Physico-chemical Properties
| Density | 1.287 g/cm3 |
| Specific Rotation(α) | D26 -64.5° (water pH 4.6) |
| Water Solubility | Soluble in water and dilute aqueous buffers |
| Solubility | Easily soluble in water, milky white to varying degrees, almost insoluble in alcohol, chloroform and ether. The aqueous solution is heated to 70 ℃ or its activity is quickly destroyed in alkaline solution, but its dried product can be heat-resistant to 100 ℃ and hygroscopic |
| Appearance | White-like powder |
| Color | slightly beige |
| Odor | Odorless |
| Merck | 13,7225 |
| Storage Condition | -20°C |
| Stability | Stable. Incompatible with strong bases, alkalies, metallic salts, alcohols. |
| Sensitive | Hygroscopic |
| MDL | MFCD00081840 |
| Physical and Chemical Properties | This product is pepsin extracted from the gastric mucosa of pigs, sheep or cattle. It is a white or light yellow powder. Soluble in water, the aqueous solution is acidic. Isoelectric point pH = 1. Insoluble in ethanol, chloroform, ether. Non-toxic, with a special smell of meat; It is hygroscopic. Dry enzyme is relatively stable, heating to 1000C for 10min without inactivation. The aqueous solution starts to inactivate when heated to above 700C or above pH 6.2, and is irreversibly inactivated when pH>8. It is stable in strong acidic solution, and the optimum pH is 1.5~2. Its digestibility is strongest when it contains 0.2% ~ 0.4% hydrochloric acid (pH1.6 ~ 1.8), so it is often combined with dilute hydrochloric acid. Sugar-containing gastric protein enzyme preparation: this strain of pepsin is a white or light yellow powder diluted with lactose, glucose or sucrose; it is sweet, without mildew, and has a special smell of meat; it is insoluble in ethanol, ether, and chloroform; it is hygroscopic; the aqueous solution is acidic, and lg can digest 600g of solidified egg protein. |
| Use | Digestive medicine, used for the lack of pepsin or digestive dysfunction caused by indigestion |
Pepsin A - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R42 - May cause sensitization by inhalation R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S22 - Do not breathe dust. S24 - Avoid contact with skin. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 1 |
| RTECS | SC6132000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 35079090 |
Pepsin A - Nature
Open Data Verified Data
- This product is pepsin extracted from the gastric mucosa of pigs, sheep or cattle, white or light yellow powder. No mildew, mildew or malodor, with hygroscopicity. Soluble in water, acidic aqueous solution; Difficult to dissolve in ethanol, chloroform, ether. Dry enzyme is more stable, heat to 100 degrees C, 10 min does not live. In the water heated above 70 ℃ or pH value of more than 6.2 start inactivation, pH>8 is irreversible inactivation. It is more stable in acidic solution. The relative molecular mass of crystalline pepsin was 34500, the isoelectric point was pl = 1, and the optimum pH was 1.5~2. Pharmaceutical pepsin is a mixture of various proteolytic enzymes, containing pepsin, cathepsin, collagenase, etc., as a crude enzyme preparation. It can hydrolyze most natural protein substrates, including keratin, mucin, silk protein, protamine, etc., and is especially sensitive to peptide bonds composed of two adjacent aromatic amino acids. The hydrolysis of protein is not complete, and the products are peptone, peptide and amino acid. Its digestion to contain 0.2% ~ 0.4 hydrochloric acid (pH l.6 ~ 1.8) is the strongest, it is often combined with dilute hydrochloric acid.
- in nature, it is present in the gastric juice of mammals, birds, reptiles and fish, in the form of zymogen in the main cells of the gastric fundus, mainly in the base of the gastric mucosa.
Last Update：2024-01-02 23:10:35
Pepsin A - Preparation Method
Open Data Verified Data
- 200kg of pig gastric mucosa was added into a sandwich pot containing lOOmL water and 3.8L hydrochloric acid under stirring. When heated to 50 ℃, the acidity was homogenized by accelerating stirring, the temperature was maintained at 45-48 °c for 3-4 hours of digestion, the undigested residue was removed by filtration, and the filtrate was collected. The filtrate was stirred at room temperature to add 15% to 20% of chloroform or diethyl ether, homogenized and then transferred to a precipitating degreaser, allowed to stand for 1 to 2 days to completely precipitate impurities, filtered, and the clear liquid was separated. The clear solution was concentrated to about 1/4 of the original volume under reduced pressure below 40 °c. The concentrated enzyme solution was vacuum-dried and ball-milled to 80-100 mesh to obtain pepsin powder.
- can also be extracted from the gastric mucosa of sheep and cattle.
Last Update：2022-01-01 11:10:42
Pepsin A - Standard
Authoritative Data Verified Data
This line was prepared from pepsin extracted from the gastric mucosa of pigs, sheep or cattle. The activity of pepsin contained in each lg shall not be less than 3800 units calculated as dry product.
Last Update：2024-01-02 23:10:35
Pepsin A - Trait
Authoritative Data Verified Data
This product is white to light yellow powder; No mildew and odor; There is hygroscopicity; Aqueous acidic reaction.
Last Update：2022-01-01 13:39:50
Pepsin A - Application
Open Data Verified Data
- digestive aid. It is commonly used in indigestion caused by excessive intake of protein food, digestive hypofunction after illness recovery, and pepsin deficiency caused by chronic atrophic gastritis, gastric cancer and pernicious anemia.
- usage and dosage: take 0.3~0. 6G before or during meals, while taking dilute hydrochloric acid 0.5 ~ 2mL.
Last Update：2025-08-19 16:24:40
Pepsin A - Differential diagnosis
Authoritative Data Verified Data
take the aqueous solution of this product and add 5% tannic acid or 25% barium chloride solution to generate precipitate.
Last Update：2022-01-01 13:39:50
Pepsin A - Safety
Open Data Verified Data
- It is forbidden to combine with alkaline drugs, but not with sucralfate. Formulation: Saccharated Pepsin.
- sealed and stored in a dry place.
Last Update：2022-01-01 11:10:43
Pepsin A - Exam
Authoritative Data Verified Data
loss on drying
take this product and dry it at 100°C for 4 hours, and the weight loss shall not exceed 5.0% (General rule 0831).
microbial limit
take this product, according to the non sterile product microbial limit test: microbial count method (General 1105) and control bacteria inspection method (General 1106) inspection. The total number of aerobic bacteria in lg samples shall not exceed 5000cfu, the total number of molds and yeasts shall not exceed lOOcfu, and Escherichia coli shall not be detected. Salmonella shall not be detected in 10g of the test product.
Last Update：2022-01-01 13:39:51
Pepsin A - Titer determination
Authoritative Data Verified Data
preparation of reference solution
an appropriate amount of a tyrosine reference substance was accurately weighed, and a hydrochloric acid solution (65ml of 1 mol /L hydrochloric acid solution and 1000ml of water were added) was dissolved and quantitatively diluted to give a solution containing 0.5mg per 1 ml.
preparation of test solution
take an appropriate amount of this product, precision weighing, and add the above hydrochloric acid solution to dissolve and quantitatively dilute to make a solution containing about 0.2 to 0.4 units per 1 ml.
assay
6 tubes were taken, of which 3 were added with 1ml of the control solution and the other 3 were added with 1ml of the test solution. In a 5°C water bath, incubate for 5 minutes, add 5ml of hemoglobin test solution preheated to 37°C ± 0.5°C, shake, and accurately time, at 37°C ± 0. Reaction was carried out in a water bath at 5°C for 10 minutes. 5% trichloroacetic acid solution (5ml) was added immediately, and the mixture was shaken, filtered, and the filtrate was taken for use. Another 2 tubes were added with 5ml of human hemoglobin test solution for each precision, kept in 37°C ± 0.5°C water bath for 10 minutes, and then 5ml of 5% trichloroacetic acid solution was added, one of them was added with 1ml of test solution, and the other one was added with lml of the above hydrochloric acid solution. The solution was shaken and filtered, and the continued filtrate was taken as the blank control for the test and the reference substance respectively, the absorbance was measured at a wavelength of 0401 nm by ultraviolet-visible spectrophotometry (general), and the average values As and A1 were calculated.
Last Update：2022-01-01 13:39:51
Pepsin A - Category
Authoritative Data Verified Data
digestive aid.
Last Update：2022-01-01 13:39:52
Pepsin A - Storage
Authoritative Data Verified Data
sealed and stored in a cool and dry place.
Last Update：2022-01-01 13:39:52
Pepsin A - Pepsin tablets
Authoritative Data Verified Data
This product contains pepsin activity should not be less than 120 units.
trait
This product is a sugar-coated tablet, microscopic yellow after removal of the coating.
identification
take this product, appropriate amount, add water grinding, so that the dissolution, filtration, filtrate according to the identification test under the item of pepsin, show the same reaction.
examination
- microbial limit take this product, according to the method under the item of pepsin inspection, should comply with the provisions.
- In addition to the disintegration time should be within 30 minutes, should comply with the relevant provisions under the tablet (General rule 0101).
titer determination
take 5 tablets of this product, put them in a mortar, add an appropriate amount of hydrochloric acid solution under the item of protease titer determination, grind evenly, and transfer the whole amount to a 250ml measuring flask, dilute to the scale with the above hydrochloric acid solution, shake well, take an appropriate amount with precision, and quantitatively dilute with the above hydrochloric acid solution to prepare a solution containing about 0.2 to 0.4 units per 1 ml as a test solution, the assay was performed according to the method under pepsin.
category
Same as pepsin.
specification
120 units
storage
sealed, stored in the cool dark.
Last Update：2022-01-01 13:39:53
Pepsin A - Pepsin Granules
Authoritative Data Verified Data
This product contains pepsin activity should not be less than 480 units.
trait
This product is white-like to yellow particles.
identification
take an appropriate amount of this product, add water to grind to dissolve, filter, filtrate according to the identification test under pepsin, show the same reaction.
examination
- acidity: Take lg of this product, add 20ml of water to dissolve, and then measure it according to law (General rule 0631). The pH value should be 3.0~4.0.
- weight loss on drying this product shall be dried at 100°C for 4 hours, and the weight loss shall not exceed 5.0% (General rule 0831).
- microbial limit take this product, according to the method under the item of pepsin inspection, should comply with the provisions.
- others should comply with the relevant provisions under The granule (General Principle 0104).
titer determination
take the contents under the item of loading amount difference, mix them evenly, weigh appropriately (about 240 units equivalent to pepsin), dissolving and quantitatively diluting the hydrochloric acid solution under the item of pepsin titer determination to prepare a solution containing about 0.2 to 0.4 units per 1 ml as a test solution, the assay was performed according to the method under pepsin.
category
Same as pepsin.
specification
480 units
storage
sealed and stored in a cool and dry place.
Last Update：2022-01-01 13:39:54
Pepsin A - Saccharated Pepsin
Authoritative Data Verified Data
The pepsin of this line was prepared by dilution with lactose, glucose or sucrose. The protease activity per lg calculated on a dry basis shall not be less than 120 units or 1200 units.
trait
This product is white to light yellow powder; No mildew and odor.
identification
take the aqueous solution of this product, according to the identification test under the item of pepsin, show the same reaction.
examination
- weight loss on drying this product shall be dried at 100°C for 4 hours, and the weight loss shall not exceed 5.0% (General rule 0831).
- microbial limit take this product, according to the method under the item of pepsin inspection, should comply with the provisions.
titer determination
take this product, according to the method under the item of pepsin determination.
category
Same as pepsin.
specification
(l)lg:120 units (2 )lg:1200 units
storage
sealed, stored in a cool and dry place
Last Update：2022-01-01 13:39:54
Pepsin A - Trait
This product is white or light yellow powder, slightly sour and salty.
Last Update：2023-08-16 21:32:38
Pepsin A - Source
The stomach of the pig was sticky.
Last Update：2023-08-16 21:32:38
Pepsin A - Optimal PH
2-4。
Last Update：2023-08-16 21:32:38
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